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Acetaminophen is comparatively uniformly distributed during most human body fluids. Binding with the drug to plasma proteins is variable; only twenty% to fifty% can be sure with the concentrations encountered during acute intoxication.
In this example, combined agonist/antagonist analgesics may perhaps decrease the analgesic impact of Darvocet-N (propoxyphene napsylate and acetaminophen) and/or could precipitate withdrawal indications in these sufferers.
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